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Summarizing the available data on gallstone prevention at the time of rapid weight loss, it is clear that UDCA is effective and has few adverse drug reactions, but its use has not been very common yet.
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Dyspepsia, epigastric pain, right hypochondriacal pain and other symptoms of biliary and gallstone disease respond, often very rapidly, in about 75 to 85% of patients treated with ursodeoxycholic acid.
All of these nine adverse reactions except esophagitis were observed with the twice a day regimen at a total daily dose of 1000 mg or greater.
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Patients showing partial gallstone dissolution at that time are likely to continue improving possibly to complete gallstone dissolution with continued therapy.
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Oral administration of pharmacological doses increases this fraction in a dose-related manner, and ursodeoxycholic acid may become the major biliary bile acid (usually to 40 to 50 mol %).
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La sua funzione fisiologica è quella di regolare l'assorbimento intestinale del colesterolo, influenzandone la quota di assorbimento per derivazione dalle lipidiche digestive.
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The percentage of patients free of stones after lithotripsy with ursodiol at six months in the DNBLS was about half that reported by Sauerbruch and colleagues in Munich, even if only completely radiolucent stones are considered.
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Mild and moderate side effects did not lead to discontinuation of the study.
It is usually taken two or three times a day to treat gallstones and two times a day to prevent gallstones in patients who are losing weight quickly.
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All these agents showed some limited clinical benefit (eg, phenobarbital relieved pruritus in 50% of patients but showed no reduction of liver enzymes or bile salts) but also had significant adverse effects.
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Ursodeoxycholic acid treatment in cholesterol gallstone disease: Effects on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, biliary lipid composition and plasma lipid levels.
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The authors gratefully acknowledge the financial support of the Medical Research Council of Canada and Axcan Pharma Canada Inc.
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It diffuses across the placenta and small quantities are found in the milk of nursing mothers.
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