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Estrogens also undergo enterohepatic recirculation via sulfate and glucuronide conjugation in the liver, biliary secretion of conjugates into the intestine, and hydrolysis in the gut followed by reabsorption.
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The study also found new genetic evidence linking earlier puberty to increased risk in later life for several cancers that are sensitive to sex hormones.
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In this substudy, prior use of estrogen-alone or estrogen plus progestin therapy was reported by 26 percent of the women.
The frequency and duration of treatment will vary according to a patient's needs.
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If you take estrogens during pregnancy, your unborn child has a greater than usual chance of having birth defects.
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Liver damage is also possible, particularly with oral therapy; it may be avoided by using parenteral or transdermal delivery.
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Consistent with the WHI clinical trial, observational studies have also reported an increased risk of breast cancer for estrogen plus progestin therapy, and a smaller increased risk for estrogen-alone therapy, after several years of use.
At first, 200 to 400 milligrams (mg), divided in two doses, for at least 3 to 6 months and up to 9 months.
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Judd, vice chairman of the department of obstetrics and gynecology at the University of California at Los Angeles School of Medicine, said that some increase in estrogen after a drink was to be expected based on previous findings that alcoholic men had elevated levels of estrogen.
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