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Comparative cost efficiency (or budget impact) studies assess the actual cost of treatment that buyers or payers would incur and are considered independent of outcomes (unlike cost-effectiveness studies, which evaluate cost relative to differential outcomes).
Using a panel of human tissues, the in vitro tissue binding profile of Aranesp ä was identical to Epoetin alfa.
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For example, papain digestion of a monoclonal antibody can be used to separate Fab from Fc to allow heterogeneity characterization of each separate fragment.
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Eprex erythropoietin product, which is used to treat anemia associated with chronic kidney disease ().
MoA), agonist activity, steep dose-response curve, poorly predictive animal models, needs to be carefully and thoroughly assessed in non-clinical studies in vitro and in vivo.
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However, in another study, the differences seen in the effects of enoxaparin or dalteparin on vWF levels did not reach statistical significance.
It stimulates erythropoiesis (increases red blood cell levels) and is used to treat anemia, commonly associated with chronic renal failure and cancer chemotherapy.
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Radiation is a local treatment and the only major systemic adverse effect is fatigue.
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Before the initiation of therapy with an erythropoietic agent, iron deficiency should be ruled out ( Figure 2 Algorithm for the Differential Diagnosis among Iron-Deficiency Anemia, Anemia of Chronic Disease, and Anemia of Chronic Disease with Iron Deficiency.
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Prior to the changes made in March of 2007 in the USP-DI, both darbepoetin alpha and epoetin had accepted indications for the treatment of anemia in cancer patients when the anemia was due to chemotherapy.
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